Antibiotics Treatment for Acute Respiratory Tract Infections (ARTIs): Evaluation of Doxycycline Resistance Cases at a Community Health Center in Urban Area of Indonesia.

Danni - Ramdhani


Acute respiratory tract infections (ARTIs) are a major health problem in developing countries. This infection can occur in the upper or lower respiratory tract which is accompanied by inflammation. Doxycycline is highly recommended for the treatment of ARTIs patients allergic to penicillin. This study aimed to evaluate the effectiveness of doxycycline in the treatment of ARTIs through its antibiotic resistance rates, and identify bacteria that have been resistant to doxycycline antibiotics. This study consists of the stages of rejuvenation of clinical isolates from ARTIs patients at a community health center in the Urban Tasikmalaya area, identification of bacteria, and testing for antibiotic resistance using the paper-disk method. The results of resistance tests from 116 single clinical isolates showed that there had been resistance to doxycycline antibiotics in the treatment of ARTIs in the urban area of Tasikmalaya with a category of 64.29% being resistant; 14.29% intermediates and 21.42% are still sensitive. The results of bacterial identification showed that doxycycline was resistant to the Corynebacterium, Streptococcus, Staphylococcus, Haemophillus and Bordetella bacteria groups. Doxycycline treatment for ARTIs infection is considered not very effective. Another class of drugs as a substitute for doxycycline for patients allergic to penicillin is needed.

Full Text:



Malosh RE, Martin ET, Ortiz JR, Monto AS. The risk of lower respiratory tract infection following influenza virus infection: A systematic and narrative review. Vaccine 2018, 36(1), 141-147.

Assane D, Makhtar C, Abdoulaye D, Amary F, Djibril B, Amadou D, et al. Viral and Bacterial Etiologies of Acute Respiratory Infections among Children Under 5 Years in Senegal. Microbiology Insights 2018, 11, 1–5.

Riskesdas. Report on Basic Health Research Results (Riskesdas) West Java Province. Bandung: West Java Provincial Health Office. 2007; 57- 62.

Winarni, Al Basirun U, Sarifudin SAN. 2010. Relationship Between Parents' Smoking Behavior and Family Members Living in One House with the Incidence of ARI in Toddlers in the Work Area of the Sempor II Public Health Center, Kebumen Regency, 2009. Nursing Health Scientific Journal 6 (1).

David M Wong, Dean A Blumberg, Lisa G Lowe, Guidelines for the Uses of Antibiotics

Ramdhani D, Fitrikusuma SA, Afifi, Mustarichie R. Amoxilin resistance in the area of Tasikmalaya, West Java. J Chem Pharm Res 2016;8:873‑8.

Ramdhani D, Alfaeira, CH, Kusuma SA. Ciprofloxacin resistance among clinical isolates from acute respiratory infections (ARIs) patient at Community Health Centers in Tasikmalaya, Indonesia. Asian J Pharm Clin Res 2017;10:42.

Atlas, R. M. 2004. Handbook of Microbiological Media 3rd Edition. New York: CRC Press. 1226.

Tang XQ, Fan MZ, Li ZZ. Study on the colony phenomenon and environmental factors in the subculture of Beauveria bassiana. Acta Mycol Sin. 1996; 15(3): 188–243.

The United State Pharmacopeial Convention. 2014. The United States Pharmacopoeia (USP). 37th Edition. United States: US Pharmacopeial Convention Inc. 79-82.

Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobia Susceptibility Testing; Twenty‑Fourth Informational Supplement. USA: Clinical and Laboratory Standards Institute; 2014. p. 68‑76.

Atlas, R. M. 2004. Handbook of Microbiological Media 3rd Edition. New York: CRC Press. 1226.

Holt J.G., N.R Krieg, P. H. A. Sneath, J. T. Staley and S.T. Williams. 1994. Bergey’s Manual of Determinative Bacteriology. 9th Edition. United Stated of America: Williams and Wilkins Company.

Levinson, W and Jawetz, E. 2003. Medical Microbiology And Immunology (Examination and Board Review). 7th Edition. North America : McGraw Hill Companies.

McClelland R. Gram’s stain: The key to microbiology. MLO Med Lab Obs 2001;33:20-2, 25.

Cheesbrough M (2000). District Laboratory Practice in Tropical Countries Low Price edition, (UK, Cambridgeshire, Britain Cambridge University Press) 62 -70.


  • There are currently no refbacks.