The Use of Methanolic Extract of Annona Muricata Linn Leaves as an Effective Anti-Hyperglycemia on Mice
Abstract
Background: Extracts from various morphological parts of soursop leaf (Annona muricata Linn/Annonaceae) are widely used in many parts of the world for the management, control, and treatment of a human diseases, including diabetes mellitus (DM). This study investigates possible anti-hyperglycemia effects of methanolic extract of Annona muricata Linn in mice experimental paradigms of DM.
Materials and Methods: The mice used were divided into three experimental groups. Group A served as ‘control’ animals and received sodium citrate buffer solution in quantities equivalent to the administered volumes of methanolic extract of Annona muricata Linn. Diabetes mellitus was induced in Groups B and C by intraperitoneal injections of streptozotocin (STZ, 80 mg/kg body weight). Group C were additionally treated with methanolic extract of Annona muricata Linn (100 mg/kg body weight, PO) for two weeks.
Results: A statistically significant lower blood glucose level was found in Group C compared to Group B in sixth (215.14±78.37 vs 319.57±135.92 mg/dL) and seventh week (158.57±24.23 vs 238.85±51.35 mg/dL) of observation.
Conclusion: Daily dose of 100 mg/kg body weight methanolic extract of Annona muricata Linn administration lowers blood glucose compared to those who did not receive in mice.Full Text:
PDFReferences
Adeyemi DO, Komolafe OA, Adewole OS, Obuotor EM, Adenowo TK. Anti Hyperglycemic Activities of Annona Muricata (Linn). African Journal of Traditional, Complementary, and Alternative Medicines. 2009;6(1):62-69.
Adewole SO, Ojewole JAO. Protective Effects of Annona Muricata Linn. (Annonaceae) Leaf Aqueous Extract on Serum Lipid Profiles and Oxidative Stress in Hepatocytes of Streptozotocin-Treated Diabetic Rats. African Journal of Traditional, Complementary, and Alternative Medicines. 2009;6(1):30-41.
Wicaksono A. Kalahkan Kanker Dengan Sirsak. Jakarta: Citra Media Mandiri; 2011. ISBN: 9786028459846
Suyono S, Sudoyo A, Setiyohadi B, Alwi I, Setiati S, Simadibrat M, et al. Diabetes Mellitus Indonesia. Jakarta: Balai Penerbut FKUI; 2007.
Baratawidjaja KG, Rengganis I. Imunologi Dasar. Vol 9. 1st ed. Jakarta: Balai Penerbit FKUI ; 2006.
Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia. 2000;43(12):1528-1533. doi: 10.1007/s001250051564.
Suryani N, Endang H, Aulanni'am A. Pengaruh Ekstrak Metanol Biji Mahoni terhadap Peningkatan Kadar Insulin, Penurunan Ekspresi TNF-αdan Perbaikan Jaringan Pankreas Tikus Diabetes. Jurnal Kedokteran Brawijaya. 2013;27(3):137-145. doi: 10.21776/ub.jkb. 2013.027.03.3.
Hidayati NA, Listyawati S, Setyawan AD. Kandungan Kimia dan Uji Antiinflamasi Ekstrak Etanol (Lantana camara L.) Pada Tikus Putih (Rattus norvegicus L.) Jantan. Bioteknologi. 2008;5(1):10-17. DOI: 10.13057/biotek/c050102
Sandhar HK, Kumar B, Prasher S, Tiwari P, Salhan M, Sharma P. A review of phytochemistry and pharmacology of flavonoids. Internationale Pharmaceutica Sciencia. 2011;1(1):25-41.
Wulandari, C. E. (2010) Pengaruh Pemberian Ekstrak Bawang Merah (Allium Ascalonicum) Terhadap Penurunan Kadar Glukosa Darah. Diponegoro University. Available at: http://eprints.undip.ac.id/23180/.
Purwatresna, E. (2012) Aktivitas Antidiabetes Ekstrak Air dan Etanol Daun Sirsak Secara In Vitro Melalui Inhibisi Enzim α-Glukosidase, Faculty of Mathematics and Natural Sciences. Indonesian Institute of Agriculture (IPB). Available at: https://repository.ipb.ac.id/handle/123456789/58641
Kumari M, Jain S. Tannins: An Antinutrient with Positivee Effect to Manage Diabetes. Research Journal of Recent Sciences. 2012;1(12):70-73.
Hernawan UE, Sutarno, Setyawan AD. Aktifitas Hipoglikemik dan Hipolipidemik Ekstrak Air Daun Bungur (Lagerstroemia speciosa [L.] Pers.) Terhadap Tikus Diabetik. Biofarmasi. 2004;2(1):15-23
Refbacks
- There are currently no refbacks.
