Nephrotoxicity: protection of silica nanoparticles loaded sodium salicylate and ginger in experimental rats
Abstract
Background: Ultrasound-assisted sol−gel method was used to prepare hollow structured porous silica nanoemulsion loaded with sodium salicylate as a model drug. Objective: This work was extended to achieve the target of the current work via investigating the protective role this nanoemulsion model as anti-inflammatory drug or ginger for its antioxidant effect against cisplatin-induced nephrotoxicity in male albino rats. Results: The results clarify that the nanoemulsion model was synthesized using ultrasonic assisted with small size and well stabilization as proved by TEM and DLS analysis. Additionally, blood urea and serum creatinine were increased after cisplatin injection with disorders in oxidative stress and rising of homocysteine levels. Also, histopathological changes of the kidney tissue were observed. These changes back to normal via treatment with silica nanoparticles loaded sodium salicylate (Si-Sc-NPs), ginger or both. Oil /water nanoemulsion of (Si-Sc NPs) and ginger showed a protective and promising preventive strategy against nephrotoxicity due to their antioxidant and anti-inflammatory effects.
Full Text:
PDFReferences
Liebler DC, Guengerich FP, (2005) Elucidating mechanisms of drug-induced toxicity. Nature reviews Drug discovery, 4: 410.
Fisel P, Renner O, Nies AT, Schwab M, Schaeffeler E, (2014) Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research, Expert opinion on drug metabolism & toxicology, 10: 395-408.
Tiong HY, Huang P, Xiong S, Li Y, Vathsala A, Zink D (2014) Drug-induced nephrotoxicity: clinical impact and preclinical in vitro models. Molecular pharmaceutics, 11: 1933-1948.
Naughton C (2008) Drug-induced nephrotoxicity, American family physician. 78.
Ma Q, Devarajan S R, Devarajan P (2016) Amelioration of cisplatin-induced acute kidney injury by recombinant neutrophil gelatinase-associated lipocalin, Renal failure, 38 : 1476-1482.
Karasawa T, Steyger P S (2015)An integrated view of cisplatin-induced nephrotoxicity and ototoxicity, Toxicology letters, 237: 219-227.
Yao X, Panichpisal K, Kurtzman N, Nugent K (2007) Cisplatin nephrotoxicity: a review, The American journal of the medical sciences, 334 : 115-124.
Kawai Y, Taniuchi S, Okahara S, Nakamura M, Gemba M (2005) Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation, Biological and Pharmaceutical Bulletin, 28 : 1385-1388.
Arany I, Safirstein RL (2003) Cisplatin nephrotoxicity, Seminars in nephrology, Elsevier, pp. 460-464.
Humanes B, Lazaro A, Camano S, Moreno-Gordaliza E, Lazaro JA, Blanco-Codesido M, Lara JM, Ortiz A., Gomez-Gomez MM, Martín-Vasallo P (2012) Cilastatin protects against cisplatin-induced nephrotoxicity without compromising its anticancer efficiency in rats, Kidney international, 82: 652-663.
Davis C A, Nick H S, Agarwal A (2001) Manganese superoxide dismutase attenuates cisplatin-induced renal injury: importance of superoxide, Journal of the American Society of Nephrology, 12" 2683-2690.
Durak İ, Özbek H, Karaayvaz M, Öztürk H S (2002) Cisplatin induces acute renal failure by impairing antioxidant system in guinea pigs: effects of antioxidant supplementation on the cisplatin nephrotoxicity. Drug and chemical toxicology, 25: 1-8.
Vinken P, Starckx S, Barale-Thomas E, Looszova A, Sonee M, Goeminne N, Versmissen L, Buyens K, Lampo A (2012) Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats, Toxicologic pathology, 40 : 1049-1062.
Shastry S, Ingram A, Scholey J, James L (2007) Homocysteine induces mesangial cell apoptosis via activation of p38-mitogen-activated protein kinase, Kidney international, 71; 304-311.
Li N, Chen L, Muh RW, Li P-L (2006) Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats, Hypertension, 47: 1094-1100.
Shankar A, Wang JJ, Chua B, Rochtchina E, Flood V, Mitchell P (2008) Positive association between plasma homocysteine level and chronic kidney disease, Kidney and Blood Pressure Research. 31: 55-62.
Jo S-K, Cho WY, Sung S.A, Kim HK, Won N.H (2005) MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis, Kidney international, 67: 458-466.
Ramesh G, Reeves WB, (2004) Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-α, Kidney international, 65: 490-498.
Heeba GH, Abd-Elghany MI (2010)Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats, Phytomedicine, 17: 1076-1081.
Aryaeian N, Tavakkoli H (2015) Ginger and its effects on inflammatory diseases, Adv Food Technol Nutr Sci Open J, 1: 97-101.
Surh Y-J (2002) Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review, Food and Chemical Toxicology, 40: 1091-1097.
Mannaa F, Ahmed H, Estefan S, Sharaf H, Eskander E (2005) Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats, Die Pharmazie-An International Journal of Pharmaceutical Sciences, 60: 689-695.
Young D S, Pestaner L, Gibberman V (1975) Effects of drugs on clinical laboratory tests.
Young DS, Keffler S, (1994) Effects of Pre Analytical Variables on Clinical Laboratory Tests, Annals of Clinical Biochemistry, 31: 398-399.
Ruiz-Larrea MB, Leal AM, Liza M, Lacort M, de Groot H, Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes, Steroids, 59 (1994) 383-388.
Moshage H, Kok B, Huizenga JR, Jansen P (1995) Nitrite and nitrate determinations in plasma: a critical evaluation, Clinical chemistry, 41: 892-896.
Patil SP, Jain PD, Sancheti JS, Ghumatkar PJ, Tambe R, Sathaye S (2014) Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice, Neuropharmacology, 86: 192-202.
Hussein J, A Razik T.E, El-Banna M, (2015) Pre-Administration Of Curcumin Prevents Hyperhomocysteinemia In Ethanol-Induced Gastric Ulcer 4 (07) 30 - 34.
Shi X, Liao S, Mi H, Guo C, Qi D, Li F, Zhang C, Yang Z (2012) Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats, Molecules, 17: 12868-12881.
Autrup H, Barile FA, Blaauboer BJ, Degen GH, Dekant W Dietrich D, Domingo JL, Gori GB, Greim H, Hengstler J., (2015) Principles of pharmacology and toxicology also govern effects of chemicals on the endocrine system, Toxicological Sciences, 146: 11-15.
Golan DE, Tashjian A, Armstrong EJ (2011) Principles of pharmacology: the pathophysiologic basis of drug therapy, Lippincott Williams & Wilkins.
Damião MJ, Giannocco G, Grespan R, Silva EL, Duarte JS, Maciel RM, Yamada A N, Bersani-Amado CA, Cuman RK (2013) Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice, Tropical Journal of Pharmaceutical Research, 12: 959-965.
Erdinç M, Erdinç L, Nergiz Y, Kelle İ, (2007) The effects of nifedipine on renal perfusion pressure and kidney during cisplatin-induced nephrotoxicity in rats. Dicle Tıp Dergisi, 34: 248-253.
Liu Q, Hu S, He Y, Zhang J, Zeng X, Gong F (2017) The protective effects of Zhen-Wu-Tang against cisplatin-induced acute kidney injury in rats, PloS one, 12: e0179137.
Muriach M, Flores-Bellver M, Romero FJ, Barcia JM, (2014) Diabetes and the brain: oxidative stress, inflammation, and autophagy, Oxidative medicine and cellular longevity, Volume 2014, Article ID 102158, 9 pages.
Moreira PI, Cardoso SM, Pereira CM, Santos MS, Oliveira CR, (2009) Mitochondria as a therapeutic target in Alzheimer's disease and diabetes, CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 8: 492-511.
Jafari I. Anarkooli, Sankian M, Ahmadpour S, Varasteh A.-R, Haghir H (2008) Evaluation of Bcl-2 family gene expression and Caspase-3 activity in hippocampus STZ-induced diabetic rats, Experimental diabetes research Volume 2008, Article ID 638467, 6 pages.
Alan M, The methionine-homocysteine cycle and its effects on cognitive diseases-Homocysteine Alternative medicine review: a journal of clinical therapeutic 8(1):7-19 .
Hussein J, El-Bana M, Refaat E, El-Naggar ME, (2017)Synthesis of carvacrol-based nanoemulsion for treating neurodegenerative disorders in experimental diabetes, Journal of Functional Foods, 37: 441-448.
Ho PI, Collins SC, Dhitavat S, Ortiz D, Ashline D, Rogers E, Shea TB (2001) Homocysteine potentiates β‐amyloid neurotoxicity: role of oxidative stress, Journal of neurochemistry, 78: 249-253.
James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA, (2004) Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism, The American journal of clinical nutrition, 80: 1611-1617.
Anoop S, Jie J,Wang B, Chua E, Rochtchina V and Flood P (2008): Positive Association between Plasma Homocysteine Level and Chronic Kidney Disease Kidney Blood Press Res, 31:55–62.
Van Guldener C (2006) Why is homocysteine elevated in renal failure and what can be expected from homocysteine-lowering?, Nephrology Dialysis Transplantation, 21: 1161-1166.
Refbacks
- There are currently no refbacks.
