Biochemical Study in Rats Hepatotoxicity with Carbon Tetrachloride and Treated with Camel Milk

Abstract

Objective: Carbon tetrachloride (CCl₄) is a highly toxic chemical agent. Therefore, the present study was carried out to investigate the protective effects of camel's milk against CCL₄ induced toxicity in male rats. Materials and methods:  Albino male rats (150-200 g) were divided into four groups of 6 rats: a control group fed only with diet and tap water for two weeks, the second group fed with standard diet and camel milk, the third group intoxicated with CCl₄ on first two days of the experimental 14 days and fed with tap water and diet, and the fourth group intoxicated with CCl₄ on first two days of the experimental 14 days and then treated with camel milk. Results: The results indicated that the CCl₄ caused a significant increased in the level of  serum total cholesterol(TC) , triglycerides(TG), very low density lipoprotein (VLDL)and low density lipoprotein(LDL), lactate dehydrogenase(LDH), creatine kinase(CK)and aspartate aminotransferase (AST). Also, there was a significant decreased in the level of serum high density lipoprotein (HDL).Protective activity of camel's milk against toxicity of CCl₄  observed in decreasing of TC, TG, VLDL, LDL, LDH, CK, AST and increased in the HDL levels. Conclusion:  These findings strongly prove that beneficial effects of Camel Milk clearly shown through the reduction of the CCl4 induced related damages and oxidative stress

Keywords: Camel milk, Carbon tetrachloride, Lipid profile, Rats.