Association of -34 T > C CYP17 Gene Polymorphism with Benign Prostatic Hyperplasia in Babylon Province, Iraq

Abdulsamie H. Altaee


Benign prostatic hyperplasia (BPH) is the most common benign tumor in men, and its incidence is age-related. This study aims to investigate the effect of -34 T > C CYP17 gene polymorphism on BPH susceptibility and clinical progress.Fifty males patients with BPH clinically diagnosis attended to Al-Hillah Teaching Hospital, as well as fifty males apparently healthy control in a case-control study were subjected to present study. The -34 T > C CYP17 gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.Genetic analysis of -34 T > C CYP17 gene polymorphism shows a significantly higher difference when comparing patients with the control groups. The dominant and codominant models of -34 T > C CYP17 gene polymorphism were shown significant change when compared with healthy control The T/C-T/T is genotyping responsible and related to the risk of BPH.In conclusion, -34 T > C CYP17 gene polymorphism could have an important role in the development and pathogenesis of BPH.

Kewords: Benign prostatic hyperplasia, CYP17 gene polymorphism, PCR-RFLP, Babylon, Iraq.

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