Molecular Study for Association of ABCB1 Gene Polymorphism with Leukemia Patients

Abstract

Yield of ABCB1 quality diversions of the advocates as an efflux particle spat that ship a gigantic sort of substrates and is an escapement of single adaptable cell security against xenobiotics. An ontogenesis (prenominal), incremental tally of weigh have demonstrated that some ABCB1 polymorphisms may expand Pgp wording and agility, and in addition influencing the advancement and feeling to illnesses and pharmacologic answer. High gayety of Pgp has been finding in established myeloid Leukemia patients. Genotyping of outstanding 12 was impact by PCR examination utilizing particular ground works. The subsequent DNA parts were conceived on agarose gels.

Keywords: ABCB1; MDR1; P-glycoprotein; Polymorphism; Exon26 & 21.