Evaluation of IL-27 Concentration in a Miscarriages Woman Infected with Toxoplasma gondii

Abstract

Toxoplasmosis is one of the most common zoonotic pathogens worldwide; Immune response against this parasite was affected by synthesis of specific interleukins like IL-27. The major objectives of this study detection of prevalence expression of IL-27 among ninety-six miscarriages women were tested; forty-eight of them was with miscarriages due to toxoplasmosis and forty-eight apparently healthy pregnant women (with out of any miscarriages) were enrolled as a control group in Najaf governorate. Methodology: Descriptive case-control, purposive (probability) sample among ninety six miscarriages women were tested, attending in Central Health Laboratory .The data collected from January 2019 to September 2019. The concentration level of IL-27 in miscarriages women was measured  by ELISA technique according to many parameters such as age, occupation, residence and number of miscarriages. The result indicated that the concentration of IL-27 was elevated in women with one or two miscarriages. The high concentration of IL-27 in infected miscarriages women with age group (20-24), (25-29).There was no significant differences in study groups according to occupation and there were differences in IL-27 concentration levels according to residency. It was demonstrated that the high concentration of IL-27 was appear in rural infected miscarriages women and low in urban miscarriages women with toxoplasmosis, results were analyzed by using statistical methods (Levene test, ANOVA test, t test). Conclusion:  Interleukins (IL-27) play a significant role in immunity against infection with Toxoplasma gondii. Recommendation: Further studies are recommended to know the concentration of IL-27 among miscarriages women to be one of an important laboratory tests in the induction of immune response against this type of infection.

Keywords: Interleukins IL-27, Toxoplasma gondii, Miscarriages women.