Synthesis and Spectroscopic Studies of Some Heterocyclic Compounds (Oxazepane -4, 7-Dione, Azetidin-2-one) Derived from 2-Chloro -1, 8-Naphthyridine-3-Carbaldyhyd and Studying their Bacterial Activity

Abstract

Some new 2-chloro -1,8-Naphthyridine-3-carbaldyhyd  (K₁) has been synthesized using N-acetyl-2-amino pyridine with through Vilsmeier-Haack cyclization to  preparation the compounds of Synthesis of  3-chloro-4-(2-chloro1,8-Naphthyridine-3-yl)-1-phenylenazetidin-2-one by ring closer reaction through the reaction of the compound (K_5-7) with chloro acetyl chloride in presence of drops of tri ethyl amine in 1,4-dioxane ,andas has been prepared (R) 2-(2-chloro1,8-Naphthyridine-3-yl)-1-phenyl-1,3-oxazepane-4,7-dione from reaction the compound (K_8-10) with  of Malic anhydride ,The newly synthesized compounds were characterized by spectroscopic evidences such as IR and ¹H NMR. The synthesized compounds were screened for their in vitro antibacterial activity, compounds were shown good activity.

Keywords: 1, 8-naphthyridine, Vilsmeier-Haack, Azetidine, Oxazepane-4, 7-Dione.