IN VITRO COMPARISON OF OSTEOGENIC DIFFERENTIATION POTENTIAL BETWEEN BONE MARROW STEM CELLS AND ADIPOSE TISSUE MESENCHYMAL STEM CELLS : A SYSTEMATIC REVIEW
Abstract
Abstract
Introduction. Bone tissue engineering (BTE) becomes a promising issue to improve bone defect repair. Stem cells are the first choice in BTE due to the ability of selfrenewal and multi-lineage differentiation. Adipose tissue (AT) is another alternative source that can be obtained by a less invasive method and in larger quantities than bone marrow.
Materials and Method. Literature search was conducted using several search engines, such as Cochrane, Scopus, PubMed, EBSCO, and Google Scholar. Studies were screened for inclusion and exclusion criteria.. This review used all In vitro experimental comparison of Mesenchymal Stem Cells (MSCs) derived from adipose tissue and bone marrow. We compared osteogenic differentiation potential between these MSCs. The group of comparison is divided into two sub groups, first group is the comparison among the animal MSCs, and the second group is the comparison among the human MSCs
Result and Discussion. From three invitro study and one animal study that compares osteogenic activity of MSC from adipose and MSC from bone marrow, Most of the study shows the osteoblastic differentiation of ATMSCs as demonstrated by AP staining was less than that of the BMMSCs. The amount of matrix mineralization shown by Von Kossa staining also showed statistical differences between the two MSCs.
Conclusion. ATMSC have differentiation potential similar to that of BMMSC, ATMSC may be a better source for tissue repair in the respect of their abundance and accessibility.
Keyword: Osteogenic differentiation, Mesenchymal Stem Cells, Adipose Tissue Mesenchymal Stem Cells.
Full Text:
PDFReferences
Barry FP MJ. Mesenchymal stem cells: Clinical applications and biological characterization. Int J Biochem Cell Biol. 2004;36(4):568–584.
Stenderup K, Justuesen J, Clausen C et al. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 2003;33:919 –926.
Zuk PA, Zuh M, Ashjian P et al. Human adipose tissue is a source ofvmultipotent stem cells. Mol Biol Cell 2002;13:4279 – 4295.
Drosse I, Volkmer E, Capanna R, De Biase P, Mutschler W SM. Tissue engineering for bone defect healing: an update on a multi-component approach. Injury. 2008;39:S9-S20.
Woodbury D, Reynolds K BI. Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J Neurosci. 2002;69:908-917.
Aust L, Devlin B, Foster SJ, Halvorsen YD, Hicok K, du Laney T, Sen A, Willingmyre GD, Gimble JM. Yield of human adipose-derived adult stem cells from liposuction aspirates. Cytotherapy. 20046 :7–14.
De Ugarte DA, et al. Comparison of Multilineage Cells from Human Adipose Tissue and Bone Marrow. Cells Tissue Organs. 2003;174:101-109
Im GI, ShinYW, Lee KB. Do Adipose Tissue – derived Mesenchymal Stem Cell have The Same Osteogenic and Chondrogenic potential as Bone Marrow Derived Cells ? Osteoarthritis and Cartilage. 2005; 13:845-853
Wagner W et al. Comparative Characteristic of Mesenchymal Stem Cells for Human Bone Marrow, adipose tissue and umbilical cord blood. Experimantal Hematology.2005;33:1402-1416
Kern S, Eichler H, Stoeve J, Kluter H, Biebeck K. Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood or Adipose Tissue.2004;24:1294-130
Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI,Mizuno H, et al. Human adipose tissue is a source of multipotent stem cells. Moll Biol Cell 2002;13:427
Winter A, Breit S, Parsch D, Benz K, Steck E, Hauner H, et al. Cartilage-like gene expression in differentiated human stem cell spheroids. Arthritis Rheum 2003;48: 418
Grande DA, Southerland SS, Manji R, Pates DW, Schwartz RE. Repair of articular cartilage defects using mesenchymal stem cells. Tissue Eng 1995;1:345
Grogan SP, Barbero A, Winkelmann V, Fizsimmons J, O’Driscoll S, Martin I, et al. Development of a visual histological grading system to evaluate tissue engineered cartilage. Transactions of the 51st annual meetings of the Orthopaedic Research Society 2005: 1678
Refbacks
- There are currently no refbacks.
