Correlation of Myeloperoxidase Activity with Malondealdehyde Levels in Iraqi Patients with Coronary Artery Diseases

Abstract

Background and Objective: Coronary Artery Disease (CAD) is one of the largest cause of mortality worldwide. The majority of CAD is caused by atherosclerosis, which is the main pathophysiological process underlying of CAD. The purpose of the current study was to investigate the role of myeloperoxidase (MPO) activity in coronary artery disease besides to its relationship with malondealdehyde levels, Athrogenic Index of Plasma (AIP) value and its association with the risk of future evolution of CAD in sera of Iraqi patients. Methods: Two main groups were included in this study; 60 patients (35male&25female) with coronary artery disease, and 40 (23male& 17female) apparently healthy controls comparable for age were enrolled in the current study. The blood samples were obtained for measurements of MPO activity, lipid profile, MDA levels and AIP value; for all participants. Results: The obtained results showed that there was a significant increases in serum MPO activity and MDA levels in coronary artery disease (46.35 ± 5.13 U/L) and (6.44 ± 1.32 nmol/ml) as compared with the control (29.12 ± 4.88 U/L) and (2.75 ± 0.43 nmol/ml), respectively. Meanwhile a highly significant increase in AIP value in CAD patients group in comparison to control group (0.36 ± 0.08, 0.076 ± 0.04),  respectively. The activity of MPO was significantly correlated with MDA levels (r=0.751, p=0.000) and AIP value (r=0.762, p=0.000). Conclusion: According to the obtained results, MPO activity, levels of MDA and AIP value were elevated in patients with CAD. It can be concluded that higher MPO activity and its correlation with high MDA levels and AIP value may be associated with complications of CAD in the Iraqi patients.

Keywords: Coronary Artery Diseases, Myelopreoxidase, Lipid peroxidation, Atherogenic Index of Plasma.