Hospitalized Adults with Acute Bacterial Meningitis: Etiology and Antimicrobial Susceptibility Profiles

Abstract

Eeffective management of acute bacterial meningitis depending on the diagnosis of bacteria that cause disease, as well as, identification of the effective antibiotic or antibiotics against most of these causative agents, the objective of this study was to detect the causative agents of acute bacterial meningitis isolated from C.S.F of inpatients adults. Since June 2017 and July 2018; 135 C.S.F. specimens were collected, 53 (39.26 %) were positive for C.S.F culture, and 71 specimens were negative. Of 53 acute meningitis patients, there were 66% male and 34% female, predominant causative agents was S. pneumoniae (20.8%), followed by N. meningitides (18.9%) and K. pneumoniae (15.1%). Antimicrobial susceptibility profiles differ depending on the causative agents, the results shows a high sensitivity to Amikacin, Vancomycin, Gentamicin, and  Ciprofloxacin, S. pneumoniae were high sensitive to Vancomycin, Gentamicin, Chloramphenicol, as well as, Ciprofloxacin, While H. influenzae  and N. meningitides exhibited considerable susceptibility to Chloramphenicol.

Key words: Meningitis; C.S.F; Antibiotics.