The Association between Plasma Soluble ICAM-1 and Adiponectin with Over Nutrition in Pediatric Patients with Dengue Infection

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is one of the urgent health problems in tropical countries, including Indonesia. On the other hand, the prevalence of overweight is also increasing among children even in developing countries. Recent studies proved that adiponectin has significant influence toward immune system. Therefore, this study aimed to provide a preliminary data about the relationship between overweight and DHF with sICAM-1 as the biomarker. Method: An analytic observational study with nested case control study design was conducted using 78 subjects. The DHF status was established using 1997 WHO criteria while the sICAM-1 and Adiponectin were assessed using ELISA technique. All of the data were statistically analyzed. Result: The baseline characteristics of the subjects between the groups were considered homogenous. The Odds ratio of overweight toward the risk of dengue shock syndrome (DSS) was found to be quite high at 2.89 (95% CI: 0.81 – 12.25) while the adiponectin level was also significantly different between overweight and normal subjects in DHF group. However, no significant difference was found in sICAM-1 level between the groups. Conclusion: It can be concluded that sICAM-1 and adiponectin level was differ between patient with over-nutrition than normal counterparts with over-nutritional patients tended to have higher sICAM-1 and lower adiponectin level. But the difference was not statistically significant.

Keywords: Dengue hemorrhagic fever, Overweight, sICAM-1, Dengue shock syndrome.