Antioxidant Potential, Total Phenolic and Flavonoids Content of Aerial Parts of Ethanolic Extract of Cordia Obliqua
Abstract
Objective: The aim of this work was to estimate the total phenolic and flavonoids content, and to evaluate in-vitro antioxidant activity of ethanolic extract of Cordia obliqua.
Methods: The ethanolic extract of Cordia obliqua was examined by Iron chelating activity, Total antioxidant activity, Total phenol and flavonoids with reference standard EDTA (Ethylenediaminetetraacetic acid), Ascorbate and catechol respectively through in vitro models.
Results: The antioxidant activities of the extract were positively associated with the total phenolic and flavonoid contents of the ethanolic extract of cordia obliqua.
Conclusion: Ethanolic extract of Cordia obliqua. showed strong scavenging activity. These in vitro assays indicate that this plant extract is a better source of natural antioxidants. The presence of antioxidants such as phenolics, flavonoids, tannins and proanthocyanidins in plants may provide protection against a number of diseases including cancer, neurodegeneration and inflammation.
Full Text:
PDFReferences
I. Gulcin.Antioxidant activity of food constituents: An overviewArch. Toxicol., 2012; 86:345-391
B. HalliwellOxidative stress and cancer: have we moved forward? Biochem. J., 2007; 401:1-11
B. Halliwell. Oxidative stress and neurodegeneration: where are we now? J. Neurochem.,2006; 97:1634-1658
L.R. Ferguson. Chronic inflammation and mutagenesis Mutat. Res. Fund. Mol., 2010; 690:3-11
Hatano T, Edamatsu R, Mori A, et al., Effect of interaction of tannins with co-existing substances. VI. Effects of tannins and related polyphenols on superoxide anion radical and on DPPH radical. Chemical and Pharmaceutical Bulletin 1989; 37: 2016– 2021.
Salah N, Miller NJ, Paganga G, Tijburg L, Bolwell GP and Rice Evans C. Polyphenolic flavonoids as scavengers of aqueous phase radicals and as chain-breaking antioxidants, Arch Biochem Biophys, 1995; 322(2): 339-346.
Parmar C, Kaushal MK. Wild fruits of the Sub-Himalayan region. Wild fruits of the Sub-Himalayan region. 1982.
Gupta R, Gupta GD. A review on plant Cordia obliqua Willd. (Clammy cherry). Pharmacognosy reviews 2015;9:127.
Kritikar KR, Basu BD. Dehradun: Shiva offset press: Indian medicinal plants.1998. p.1674-81.
Thirupathi K, Kumar SS, Raju VS, Ravikumar B, Krishna DR, Mohan GK. A review of medicinal plants of the genus Cordia: Their chemistry and pharmacological uses. Journal of Natural Remedies 2008;8 Suppl 1:1-10.
Yadav R, Yadav SK. Evaluation of antimicrobial activity of seeds and leaves of cordia obliqua Willd. against some oral pathogens. Indo-American Journal of Pharmaceutical research 2013;3:6035-6043.
Agnihotri VK, Srivastava SD, Srivastava SK, Pitre S, Rusia K. Constituents from the seeds of Cordia obliqua as potential anti-inflammatory agents. Indian Journal of Pharmaceutical Sciences 1987;49:66-9.
Abou-Shaaban RR, Al-Angari AA, El-Tahir KE, Al-Khamis KI, Mirghani OM. Comparative hypotensive and respiratory stimulation effects of ripe and unripe fruit mucilage of Cordia myxa and Cordia obliqua in guinea pigs and rabbits. Phytotherapy Research 1989;3 Suppl 4:126-31.
Sivakrishnan S, Kottaimuthu A. Hepatoprotective activity of ethanolic extract of aerial parts of Albizia Procera Roxb (Benth.) against paracetamol induced liver toxicity on wistar rats. International journal of pharmacy and pharmaceutical sciences 2014; 6 Suppl 1: 233-238.
Sivakrishnan S, Kottaimuthu A. Kavitha J. GC-MS analysis of ethanolic extract of aerial parts of Albizia procera (Roxb) Benth. International journal of pharmacy and pharmaceutical sciences 2013;5 Suppl 3:702-704.
Sivakrishnan S, Kottaimuthu A. Kavitha J. Antioxidant Potential, Total Phenolic And Flavonoids Content of aerial parts of ethanolic extract of Albizia Procera (Family: Mimosoideae). Asian J Pharm Clin Res, Vol 6, Suppl 1, 2013, 108-110.
Benzie IEF and Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 1996;239,70-76.
Prieto, P., Pineda, M., Aguilar, M. Spectrophotometric quantitation of antioxidant capacity through the formation of a Phosphomolybdenum Complex: Specific application to the determination of vitamin E. Anal. Biochem, 1999;269,337-341.
Mallick CP and Singh MB. Plant enzymology and Histoenzymology (eds), Kalyani publishers, New Delhi, 1980; 286.
Cameron GR, Milton RF and Allen JW. Measurement of flavonoids in plant samples. Lancet, 1943; 179.
Refbacks
- There are currently no refbacks.
