The Effect of Calcium Oxide Nanoparticles on Liver Enzymes in White Rats

Abstract

Calcium is the five elements that found on the crust of the earth. It`s the essential mineral for all organisms because the important role in the functions of the life cells , and its essential mineral for binding the bone and teeth by producing calcium phosphate. The decreasing of calcium element in the body leads to weakness, dental caries, and muscle cramps. Present study was designed to evaluate the effect of calcium oxide- nanoparticles on the serum levels for liver enzymes of white rats. Two group of White rats ( 3 rats each group) received calcium oxide- nanoparticles which were orally administered with 50 and 100 (mg/kg) from of body weight of calcium oxide- nanoparticles suspension daily for 10 day. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured at start and at the end of the study.  Changes of the specific parameters indicated that liver were significantly affected in both experimental groups , the changes between the levels of total alanine aminotransferase , aspartate aminotransferase and alkaline phosphatase indicate that calcium oxide- nanoparticles induces liver damage and may be lead to hepatic toxicity in the experimental rats.

Key words: CaO-Nanoparticles, (ALT, AST and ALP), White rats.