Antidotal Therapeutic Trials of Induced Acute Sulphur Toxicosis in Male Rats

Abstract

Objective: The current study is planned for treatment of sulphur acute poisoning as laboratory animals model in male rat. Method: Primarily, oral LD₅₀ estimated by probit method and derived statistically by two different statistic programs, Microsoft excel and Spss version 25, the estimated LD₅₀ was 4102 and 4060 respectively which exhibited no statistical differences. After that the toxic nonfatal dose 3000 mg/Kg.BW was chosen and administered through gastric gavag as a single dose to 18 male rats divided equally and assigned as, G1injected I.P by solution contain (0.6 % sodium nitrate + 6% sodium thiosulfate) plus 0.1 ml B-complex per each 100 gm BW, G2 also injected I.P by barium chloride 160 mg/kg.BW plus 0.1 ml B-complex/100gm .BW, while the third group didn’t receive any anti-dote and considered control group. Results: The result revealed that both anti-dotes have various efficiency to overcome acute sulphur poisoning in rat, but barium chloride plus B-complex was the more efficient one. Conclusion: Barium chloride plus B-Complex I.P antidote is capable to overcome sulphur acute poisoning in rat, but further studies are recommended in ruminants

Keywords: Treatment, Acute, Toxicity, Sulphur, Rat.