Synthesis of New γ-Lactam Derived from 3-Chlorobenzo [b] Thiophene and Evaluation of Anti Bacterial Activity

Abstract

New hetero cyclic, compounds derived from cinnamic acid was synthesized. 3-Chlorobenzo[b]thiophene-2-carbonyl (Z₁) was synthesized from cinnamic acid and thionyl chloride . Carbohydrazide (Z₂) was obtained by the reaction of 3-Chlorobenzo [b]thiophene-2-carbonyl chloride (Z₁) with hydrazine hydrate. treatment of (Z₁)with ethylene di amine to give  (Z₃) .(Z₂,Z₃) undergo condensation reaction with different aromatic aldehyde in absolute ethanol gave the Schiff′s bases (Z₄-Z₁₉) new γ- lactams (Z₂₀- Z₃₅)  derivatives have been synthesized by reacting of succinic anhydride with Schiff’s bases These compounds were evaluated of the anti- bacterial activities

Keyword: benzo[b]thiophene, γ- lactams, Schiff′s bases.