Study MetheletetraHydrofolatredctase (MTHFR) Gene Polymorphism in Myocardial Infarction Patients in Babylon Province/ Iraq

Abstract

The present study was aimed to investigate MetheletetraHydrofolatredctase (MTHFR) gene which related to acute myocardial infarction (MY) patients using restriction fragment length polymorphism (RFLP-PCR) technique, the results show that the homozygote TT genotype was (23.3%) in patients and (30.0%) in control with non-significant variation (OR 1.41). while CT genotype was (30.0%) and (33.03%) in patent and control respectively  with not significantly with OR (14.414) , CC genotype was (46.7%) in patients and (36.70%) in control. The allelic frequency was T patient vs. controls; 38% vs. 47% while allelic frequency was C in the patient vs. controls; 62% vs. 53%. we have concluded that  the MTHFR 677T allele hasn’t  been contributed as a risk factor for myocardial infarction .Our findings raise the possibility that novel genetic defects and/or environmental  factors  may  influence  homocysteine  metabolism  in  this  ethnic  group.

Keywords: MetheletetraHydrofolatredctase, Acute myocardial infarction, RFLP-PCR.