Relationship between Lipid Profile and Some Physiological Markers in Pre and Post-Menopausal Type II Diabetic Females

Abstract

This study aimed to compare lipid profile level rates in pre and post-menopausal type II diabetic females. The hormones including (Estradiol and Insulin) and the physiological parameters (Cholesterol, high density lipoproteins, Triglyceride, Low density lipoproteins, Very low density lipoproteins , Hemoglobin A1c, Fasting Blood Glucose, insulin resistance, insulin sensitivity, systolic and diastolic blood pressure). This case-control study was done in a period of March 2016 to October 2016, where the samples collected from Al-Sadr Teaching Hospital in Najaf Province. The number of samples was (80) patients with type 2 diabetes with an average age (36-65 year), all of them were with type 2 diabetes are divided to premenopausal and post menopause, Also, the study included 40 apparently healthy people with an average age ( 36-65 year) , as control matched with disease group. The results showed that patients with type 2 diabetes , had significantly( p ≤ 0.05 )  higher cholesterol, Triglyceride, Low density lipoprotein, very low density lipoprotein, Hemoglobin A1c, insulin, insulin resistance and Fasting blood glucose levels rate than control group, while the levels rate of insulin sensitivity is decreased significantly (p ≤ 0.05)  in type 2 diabetic patients when compared with control group . The Estradiol levels rate was significantly (p ≤ 0.05) higher in premenopausal females while it decreased in postmenopausal females of both control and type 2 diabetic patients. Systolic and diastolic pressure showed significant difference between patients with type 2 diabetic and control. According to the comparison of premenopausal and postmenopausal women in both diabetic patients and in control group, the results showed significant ( p ≤ 0.05) elevation in Estradiol hormone level rates, Insulin hormone level rates and insulin resistance in both groups. On the other , the comparison of premenopausal patients with diabetic and  premenopausal control groups the statistical analysis showed significant elevation (p ≤ 0.05) in cholesterol levels rate, Low density lipoprotein (LDL), Hemoglobin_A1c  levels rate (HB_A1c), fasting blood glucose (FBG), Estradiol hormone level rates, Insulin hormone level rates, insulin resistance ,insulin sensitivity and diastolic blood pressure. According to the comparison of postmenopausal diabetic patients and postmenopausal control group, there were significant differences (p ≤ 0.05) in cholesterol levels rate, Low density lipoprotein (LDL), Hemoglobin_A1c levels rate (HB_A1c), fasting blood glucose (FBG), Estradiol hormone level rates, Insulin hormone level rates, insulin resistance and insulin sensitivity.

Keywords: lipid profile, Diabetes mellitus, Pre and Post-Menopausal, estradiol