The Role of Lipopolysaccharide and Tight Junction Protein-1 (Zo-1) Levels and Symbiosis of Black Rice Extract in Obese Patients

Armanto Makmun

Abstract

Excessive fat accumulation, which is commonly known as obesity, causes health problems for the community, such as metabolic disorders. Recent studies have shown that the gut micro biota is involved in the occurrence of metabolic disorders in obesity. The gut micro biota can regulate body weight by influencing metabolic processes, regulating the expression of host genes, increasing the ability to extract and store energy. Intestinal micro biota imbalance and increased plasma lipopolysaccharide (LPS) contribute to inflammation in obesity. The latest safe approach in cases of obesity is to use active ingredients from local foods. In South Sulawesi, Indonesia and also in other Asian countries found black rice as the local product that is very good for health because the high level of bioactive compounds that are important for health such as anthocyanin, proteins, amino acids, and phenolic acids. The ingredients in black rice play a role in modulating the composition of the intestinal micro biota as indicated by the increasing composition of Bifid bacterium and Lactobacillus. The increase in the composition of Bifid bacterium causes improvement in the expression of tight junction proteins in the intestinal epithelium, thereby contributing to prevent the translocation of LPS into the circulation. Apart from its role in modulating the composition of bacteria, it can also function to influence intracellular signaling.

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Liu X, Cervantes C, Liu F. Common and distinct regulation of human and mouse brown and beige adipose tissues: a promising therapeutic target for obesity. Protein Cell. 2017;8(6):446–54.

Zhang Y, Xie C, Wang H, Foss RM, Clare M, George EV, et al. Irisin exerts dual effects on browning and adipogenesis of human white adipocytes. Am J Physiol - Endocrinol Metab. 2016;311(2):E530–41.

Organization WH. Obesity and Overweight. 2018.

Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6–10.

Wang H, Liu D, Ji Y, Liu Y, Xu L, Guo Y. Dietary Supplementation of Black Rice Anthocyanin Extract Regulates Cholesterol Metabolism and Improves Gut Microbiota Dysbiosis in C57BL / 6J Mice Fed a High-Fat and Cholesterol Diet. Food Funct. 2020;64(8):1–13.

Zhang M, Zhao J, Deng J, Duan Z. Function saponin on intestinal health in antibiotic-treated. 2019;4124–33.

Sun L, Ma L, Ma Y, Zhang F, Zhao C, Nie Y. Insights into the role of gut microbiota in obesity: pathogenesis, mechanisms, and therapeutic perspectives. Protein Cell. 2018;9(5):397–403.

Turner M, Jannah N, Kahan S, Gallagher C, Dietz W. Current Knowledge of Obesity Treatment Guidelines by Health Care Professionals. Obesity. 2018;26(4):665–71.

Haslam DW, James WPT. Obesity. Lancet. 2005;366(9492):1197–209.

Organization WH. Obesity and overweight. In Switzerland: World Health Organization; 2018.

Almeida C, Missae L, Moura R De, Vera V, Rosso D, Oller C, et al. Polyphenols-rich fruit in maternal diet modulates in fl ammatory markers and the gut microbiota and improves colonic expression of ZO-1 in offspring. Food Res Int. 2015;77(2):186–93.

Morais CA, Oyama LM, Oliveira JL De, Garcia MC, Rosso VV De, Sousa L, et al. Jussara ( Euterpe edulis Mart .) Supplementation during Pregnancy and Lactation Modulates the Gene and Protein Expression of Inflammation Biomarkers Induced by trans -Fatty Acids in the Colon of Offspring. Mediat Inflamm. 2014;2014(2014):987927.

Zhang MW, Zhang RF, Zhang FX, Liu RH. Phenolic Profiles and Antioxidant Activity of Black Rice Bran of Different Commercially Available Varieties. J Agric Food Chem. 2010;58(13):7580–7.

Cremonini E, Daveri E, Mastaloudis A, Adamo AM, Mills D, Kalanetra K, et al. Redox Biology Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling , barrier integrity and dysbiosis. Redox Biol. 2019;26(June):101269.

Jang H, Park M, Kim H, Lee Y, Hwang K, Park J, et al. Black rice ( Oryza sativa L .) extract attenuates hepatic steatosis in C57BL / 6 J mice fed a high-fat diet via fatty acid oxidation. Nutr Metab. 2012;9(27):1–11.

Chen PN, Kuo WH, Chiang CL, Chiou HL, Hsieh YS, Chu SC. Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. Chem Biol Interact. 2006;163(3):218–29.

Prasad BJ, Sharavanan PS, Sivaraj R. Health benefits of black rice – A review. Grain Oil Sci Technol. 2019;2(4):109–13.

Zhu Y, Sun H, He S, Lou Q, Yu M, Tang M, et al. Metabolism and prebiotics activity of anthocyanins from black rice (Oryza sativa L.) in vitro. PLoS One. 2018;13(4).

Javadzadeh Y, Hamedeyaz S. Floating Drug Delivery Systems for Eradication of Helicobacter pylori in Treatment of Peptic Ulcer Disease. Trends Helicobacter pylori Infect. 2014;304–7.

Kang MY, Kim JH, Rico CW, Nam SH. A comparative study on the physicochemical characteristics of black rice varieties. Int J Food Prop. 2011;14(6):1241–54.

Mirmiran P, Bahadoran Z, Esfandyari S, Azizi F. Dietary protein and amino acid profiles in relation to risk of dysglycemia: Findings from a prospective population-based study. Nutrients. 2017;9(9):1–9.

Sumczynski D, Kotásková E, Družbíková H, MlÄek J. Determination of contents and antioxidant activity of free and bound phenolics compounds and in vitro digestibility of commercial black and red rice (Oryza sativa L.) varieties. Food Chem. 2016;211:339–46.

Ito VC, Lacerda LG. Black rice (Oryza sativa L.): A review of its historical aspects, chemical composition, nutritional and functional properties, and applications and processing technologies. Food Chem. 2019;301(April):125304.

Idrus HH, Hatta M, Kasim VN, Achmad AF, Mangarengi Y. Molecular Impact on High Motility Group Box-1 (HMGB-1) in Pamps and Damp. Indian J Public Health. 2020;11(1):1–8.

Boerner BP, Sarvetnick NE. Type 1 diabetes: Role of intestinal microbiome in humans and mice. Ann N Y Acad Sci. 2011;1243(1):103–18.

Wang LL, Guo HH, Huang S, Feng CL, Han YX, Jiang JD. Comprehensive evaluation of SCFA production in the intestinal bacteria regulated by berberine using gas-chromatography combined with polymerase chain reaction. J Chromatogr B Anal Technol Biomed Life Sci. 2017;1057(May):70–80.

Cueva C, Moreno-Arribas MV, Martín-Ãlvarez PJ, Bills G, Vicente MF, Basilio A, et al. Antimicrobial activity of phenolic acids against commensal, probiotic and pathogenic bacteria. Res Microbiol. 2010;161(5):372–82.

Lee HC, Jenner AM, Low CS, Lee YK. Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Res Microbiol. 2006;157(9):876–84.

Waldram A, Holmes E, Wang Y, Rantalainen M, Wilson ID, Tuohy KM, et al. Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents. J Proteome Res. 2009;8(5):2361–75.

Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Ley RE, Sogin ML, et al. A core gut microbiome between lean and obesity twins. Nature. 2009;457(7228):480–4.

Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine. 2008;42(2):145–51.

Villena J, Kitazawa H. Modulation of intestinal TLR4-inflammatory signaling pathways by probiotic microorganisms: Lessons learned from Lactobacillus jensenii TL2937. Front Immunol. 2013;4(DEC):1–13.

Saez-Lara MJ, Gomez-Llorente C, Plaza-Diaz J, Gil A. The role of probiotic lactic acid bacteria and bifidobacteria in the prevention and treatment of inflammatory bowel disease and other related diseases: A systematic review of randomized human clinical trials. Biomed Res Int. 2015;2015.

Flores G, Luisa M, Costabile A, Klee A, Bigetti K, Gibson GR. In vitro fermentation of anthocyanins encapsulated with cyclodextrins : Release , metabolism and influence on gut microbiota growth. J Funct Foods. 2015;16(2015):50–7.

Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic Endotoxemia Initiates Obesity and Insulin Resistance. Diabetes. 2007;56(July):1761–72.

Limtrakul P, Yodkeeree S, Pitchakarn P, Punfa W. Suppression of Inflammatory Responses by Black Rice Extract in RAW 264 . 7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways. 2015;16:4277–83.

Min SW, Ryu SN, Kim DH. Anti-inflammatory effects of black rice, cyanidin-3-O-β-d-glycoside, and its metabolites, cyanidin and protocatechuic acid. Int Immunopharmacol. 2010;10(8):959–66.

Guo S, Nighot M, Al-sadi R, Alhmoud T, Nighot P, Affairs V. Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR-4 signal transduction pathway activation of FAK and MyD88. J Immunol. 2016;195(10):4999–5010.

Guo S, Al-sadi R, Said HM, Ma TY. Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of. Am J Pathol. 2013;182(2):375–87.

Idrus HH, Mangarengi Y, Mustajar NS. Test of Polymerase Chain Reaction (PCR) Detection and The Specificity in Gen Hd Salmonella typhi in RS. Ibnu Sina. In: The 8th Annual Basic Science International Conference “Convergence of Basic Sciences, Toward the World’s Sustainability Challenges.†2018. p. 1.

Ma TY, Boivin MA, Ye D, Pedram A, Said HM, Thomas Y, et al. Mechanism of TNF-intestinal epithelial tight junction barrier : role of myosin light-chain kinase protein expression. 2005;0001:422–30.

Zhao L, Zhang Y, Liu G, Hao S, Wang C, Wang Y. Black rice anthocyanin-rich extract and rosmarinic acid, alone and in combination, protect against DSS-induced colitis in mice. Food Funct. 2018;9(5):2796–808.

Chen T, Hu S, Zhang H, Guan Q. Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model. Food Funct. 2017;8(2):659–69.

Han SJ, Ryu SN, Trinh HT, Joh EH, Jang SY, Han MJ, et al. Metabolism of cyanidin-3-o-β-d-glucoside isolated from black colored rice and its antiscratching behavioral effect in mice. J Food Sci. 2009;74(8).

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