Sustained release of drugs from prepared polymeric systems for Alzheimer disease protection

Doaa E El-Nashar

Abstract

Objective: Slow release technique is a trial for long-acting protection from Alzheimer. Drug delivery systems, polymer based, can be designed to improve the pharmacological and therapeutic properties. Slow release technique gave the availability of drugs to deliver the right location in the body. The main principle of this technique is holding and keeping the drug on the polymer carrier for a sustained release of medicine in the body for a long period of time. The present work aimed to prepare polymeric materials from starch cellulose acetate coacrylate (SCACA), containing sodium bentonite nano clay and tween 80 as a surfactant for improving drug loading. The objective of this formulated natural polymeric product is to obtain practical effective sustained release drug systems by evaluating its potency in vivo for protection from Alzheimer disease. SCACA biodegradable polymeric system formulations containing anti Alzheimer drugs (such as Curcumin, Rosemary or Donepezil) were investigated through oral administration in experimental animals (rats).
Methods: The characterization of the prepared polymeric system was carried out by FTIR and SEM. The drug release was measured spectrophotometrically. The invivo evaluation of the released drug against Alzheimer disease was an assessment of the effect in rats through biochemical and histopathological studies.
Results: The slow release of the drug according to the study time illustrated that Rosemary, Curcumin and Donepezil estimated values through the tested time gave promising results, especially for releasing Rosemary, Curcumin and Donepezil. In the present investigation, the biochemical findings were also confirmed by histopathological observations which showed improvements in most biochemical parameters accompanied with amelioration in histological architectures in rats treated.
Conclusions: Slow release technique is a good means for long-acting protection from Alzheimer's disease. Starch cellulose acetate coacrylate (SCACOA) is a good carrier for drugs such as Donepezil as a conventional drug while Rosemary, Curcumin as bioactive natural products. The invivo study for Alzheimer's protection gave promising results.

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References

Weller J, Budson A. Current understanding of Alzheimer’s disease diagnosis and treatment, F1000Research 2018, 7(F1000 Faculty Rev):1161. https://doi.org/10.12688/f1000research.14506.1.

-Crous-Bou M, Minguillón C, Gramunt N, et al. Alzheimer's disease prevention: from risk factors to early intervention. Alzheimers Res Ther. 2017; 9(1):71. https://doi.org/10.1186/s13195-017-0297-z.

Alzheimer's Association: 2017 Alzheimer's disease facts and figures. Alzheimers Dement. 2017;13(4):325–73. https://doi.org/10.1016/j.jalz.2017.02.001.

Santos BF, Gremião MP, Chorilli M. Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease. Int J Nanomedicine. 2015; 10: 4981 5003. https://doi.org/10.2147/IJN.S87148.

Harilal S , Jose J, Parambi DT , Kumar R, Mathew G , et al. Advancements in Nanotherapeutics for Alzheimer's Disease: Current Perspectives. J Pharm Pharmacol, 2019 Sep;71(9):1370-1383. https://doi.org/10.1111/jphp.13132.

Takizawa C, Thompson PL, van Walsem A, et al. Epidemiological and economic burden of Alzheimer's disease: a systematic literature review of data across Europe and the United States of America. J Alzheimers Dis. 2015; 43(4):1271–84. https://doi.org/10.3233/JAD-141134.

Karthivashan G, Ganesan P, Park SY, Kim JS, Choi DK. Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer's disease. Drug Deliv. 2018 Nov;25(1):307-320. https://doi.org/ 10.1080/10717544.2018.1428243.

Zhou Y, Peng Z, Seven ES, Leblanc RM. Crossing the blood-brain barrier with nanoparticles. J Control Release. 2018, 28; 270:290-303. https://doi.org/ 10.1016/j.jconrel.2017.12.015.

Hernando S, Gartziandia O, Herran E, Pedraz JL, Igartua M, Hernandez RM. Advances in nanomedicine for the treatment of Alzheimer's and Parkinson's diseases. Nanomedicine (Lond). 2016 May;11(10):1267-85. https://doi.org/ 10.2217/nnm-2016-0019.

Ruozi B, Belletti D, Pederzoli F, Veratti P, Forni F, Vandelli MA, Tosi G. Nanotechnology and Alzheimer's disease: what has been done and what to do. Curr Med Chem. 2014; 21(36):4169-85. https://doi.org/10.2174/0929867321666140716100056.

Markwalter CE, Pagels RF, Wilson BK, Ristroph KD, Prud'homme RK. Flash Nano Precipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles. J Vis Exp. 2019 Jan 7;(143). https://doi.org/10.3791/58757.

Helaly FM, El Nashar DE, Khalaf AI, Abdelhamid HF, Wietrzyk J, Psurski M, Soliman AM. Slow-Release Nanopolymeric Biodegradable Composites Holding Doxorubicin and Evaluation Its Antiproliferative Potency on Cancer. Polymer Composites. 38 (S1): 34-41, 2017. https://doi.org/10.1002/pc.23861.

Helaly FM, Khalaf AI, El Nashar DE, Abdelhamid HF, Soliman AM. Bioassay and bioactivity of polymer as carrier for some active compounds such as anticancer drugs. Res Chem. Intermed., 2014; 40: 749-760. https://doi.org/ 10.1007/s11164-012-0999-6.

Helaly FM, El Nashar DE, Khalaf AI, Abdelhamid HF, Abd El-Moez SI, Soliman AM. Slow Release of 5-fluorouracil from Natural Polymeric Composites as Controlled Drug Delivery. Int J Pharm Sci Rev Res. 2015; 30: 137-142. https:// www.globalresearchonline.net.

Helaly FM, Khalaf AI, El Nashar DE, Ragab SA, Rozik NN, Soliman AM. Evaluation of Synthesized Starch Cellulose Acetate Coacrylate and nanoclay holding drugs. Egy J Chem. 2019; 62, Special Issue (2), 549- 562. https://doi.org/10.21608/EJCHEM.2019.13963.1863.

Helaly FM, Khalaf AI, El Nashar DE. Starch cellulose acetate co acrylate (SCAA) polymer as a drug carrier. Res. Chem. Intermed. 2013; 39: 3209–3220. https://doi.org/ 10.1007/s11164-012-0833-1.

-Deacon RM, Rawlins JN. T-maze alternation in the rodent. Nat Protoc. 2006; 1: 7-12. https://doi.org/ 10.1038/nprot.2006.2.

- Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979; 95: 351-358. https://doi.org/ 10.1016/0003-2697(79)90738-.

- Meral I, Kanter M. Effects of Nigella sativa L. and Urticadioica L. on selected mineral status and hematological values in CCl4treated rats. Biol Trace Elem Res. 2003; 96(1-3): 263-70. https://doi.org/ 10.1385/BTER:96:1-3:263.

– Ensafi AA, Khayamian T, Hasanpour F. Determination of glutathione in hemolysed erythrocyte by flow injection analysis with chemiluminescence detection. J Pharm Biomed Anal. 2008 Sep 10;48(1):140-4. https://doi.org/10.1016/j.jpba.2008.04.028.

- Aebi H. Catalase in vitro. Methods Enzymol. 1984; 105: 121-126. https://doi.org/ 10.1016/S0076-6879(84)05016-3.

- Nishikimi M, Roa NA, Yogi K. The occurrence of superoxide anion in the reaction of reduced phenazinemethosulfate and molecular oxygen. Biochem. Biophys. Res. Commun. 1972; 46: 849-854. https://doi.org/ 10.1016/s0006-291x(72)80218-3.

- Goldberg DM, Spooner RG. Method for the determination of glutathione reductase. Methods Enzymatic Anal. 1983; 3: 258-265. https://doi.org/ 10.1016/0891-5849(95)02090-X.

- Blasiak J, Arabski M, Krupa R, Wozniak K, Zadrozny M, Kasznicki J, Zurawska M, Drzewoski J. DNA damage and repair in type 2 diabetes mellitus. Mutat Res. 2004 ; 554(1-2):297-304. https://doi.org/10.1016/j.mrfmmm.2004.05.011.

- Helaly FM, El Nashar DE, Khalaf AI, Salam SA, Wietrzyk J, Milczarek M, Soliman AM, Awad G. Assessment of the in vitro controlled release for some polymeric nanocomposites loaded with different drugs. Egy J Chem. 2020; 63 .https://doi.org/10.21608/ejchem.2020.18885.2161.

- Khan AA, Alzohairy MA. Hepatoprotective Effects of Camel Milk against CCL4 Induced Hepatotoxicity in Rats. Asian J Biochem. 2011; 6:171-180. https://doi.org/10.3923/ ajb.2011.171.180.

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