Synthesis and Biological Activities of Some New Derivatives Based on 2-amino-5-mercapto-1, 3, 4-Thiadiazole Containing Imide, β-Lactam Rings

Abstract

New series of 2-amino-5-mercapto-1,3,4-thiadiazole derivatives compounds are synthesized [S₁-S₄], then converted to Schiff^′s base [S₅-S₁₀] which is reacted with chloro acetyl chloride due to the existence of  𝛽-Lactam compound[S₁₁-S₁₆]. The prepared derivatives are identified by infrared spectra studies, ¹HNMR, and physical properties. The antibacterial strains have been investigated: an activity has been shown against Gram (+ve) bacterial (stapylococus and Gram (- ve) bacteria (Esherichiacoli).

Key words: 1, 3, 4-Thiadiazole, Schiff bases, Heterocyclic rings, Biological activity.